天山北坡放牧绵羊面部湿疹的临床病理学研究

doi:10.11843/j.issn.0366-6964.2013.09.021

畜牧兽医学报 ›› 2013, Vol. 44 ›› Issue (9): 1481-1486.doi: 10.11843/j.issn.0366-6964.2013.09.021

天山北坡放牧绵羊面部湿疹的临床病理学研究

刘良波¹，韩玉霞¹，孙焕林¹，柳建新¹，杨祎²，王建华³，卜万喜⁴，齐亚银¹，剡根强^1*

（1. 石河子大学动物科技学院, 石河子 832000; 2. 新疆西部牧业股份有限公司, 石河子 832000; 3. 新疆农八师一四三团, 石河子 832000; 4. 新疆农八师紫泥泉种羊场, 石河子 832000）

收稿日期:2013-01-08 出版日期:2013-09-23 发布日期:2013-09-23
通讯作者: 剡根强，Tel：0993-2058583， E-mail：ygq58@shzu.edu.cn
作者简介:刘良波(1980-)，男，四川大竹人，助教，博士生,主要从事遗传抗病机理研究，Tel: 0993-2058583， E-mail：13768963@qq.com

Clinicopathological Studies on Facial Eczema Outbreak in Grazing Sheep in Northern Slope of Tianshan Mountain

LIU Liang-bo¹, HAN Yu-xia¹, SUN Huan-lin¹, LIU Jian-xin¹, YANG Yi² , WANG Jian-hua³, PU Wan-xi⁴, QI Ya-yin¹, YAN Gen-qiang^1*

(1. College of Animal Science and Technology, Shihezi University, Shihezi 832000, China; 2. Xinjiang Western Animal Husbandry Co., Ltd., Shihezi 832000, China; 3. The XPCC., Agriculture Eighth Division 143 Corps, Shihezi 832000, China; 4. The XPCC., Agriculture 8th Division, Ziniquan, Sheep & Goat Breeding Farm, Shihezi 832000, China)

Received:2013-01-08 Online:2013-09-23 Published:2013-09-23

摘要/Abstract

摘要：

本研究为探讨放牧绵羊面部湿疹的发病机理，对天山北坡天然草场放牧绵羊面部湿疹的临床发病过程，病理解剖与组织学，血清肝功能指标进行了调查和测定；并对100只发病羊和100只健康羊及5只病死羔羊进行了真菌的分离培养和真菌类型统计学分析。结果显示，绵羊发病只在特定区域草场发病，以6月龄内细毛羊多发，以面部（耳，眼睑）及颌下炎性水肿为特征，病死羔羊肝肿大，表面有黄白色斑状坏死灶，切面有结节性硬变及纤维化，肝组织学显示肝淤血，肝细胞和胆管严重坏死，脂肪变性。发病羊血清中的谷氨酰转肽酶(GGT)活性为94.93～260.78 U·L^-1，明显高于健康羊16.47～61.59 U·L^-1，谷丙转氨酶(ALT)、总胆红素（TBIL）也明显高于健康绵羊(P<0.01)，而发病羊和健康羊的谷草转氨酶(AST)活性差异不显著(P>0.05)；发现205只试验羊都有真菌的感染，发病羊的分离菌中纸皮思霉属、链格孢菌属、镰刀菌属和曲霉属真菌4种菌的分离率较其他属真菌高，其中纸皮思霉属分离率为最高，酵母菌、根霉属和毛霉属真菌在发病羊和健康羊都有分离，但是分离率都较低。表明本地区放牧绵羊湿疹属肝功能不全和肝坏死引发的肝原性光过敏性湿疹，其病原可能为纸皮思霉属、链格孢菌属、镰刀菌属和曲霉属4种真菌。

Abstract:

To understand the pathogenesis of facial eczema of grazing sheep, the clinical disease process, pathological anatomy and histology, serum liver function parameters of facial eczema of grazing sheep in northern slope of Tianshan Mountain were investigated and determined. The fungal types isolated from 100 sick sheep, 100 healthy sheep and 5 dead lambs were analyzed by statistics. The results indicated that onset of the diseases was limited on certain areas only, and the disease most likely attacked young fine-wool sheep with the age less than 6 months old. The clinical manifestations were characterized by inflammational edema in face (ears and eyelids) and mandibular area. Postmortem examination of dead lambs showed enlargement of liver with yellow white patchs of necrotic lesion and tuberous sclerosis and fibrosis on section. Histologic examination of liver showed extravasated blood, severe lesion of liver cells and bile duct, and fatty degeneration. GGT levels of the disease animals were very high and varying from 94.93 to 260.78 U·L^-1, but the GGT in normal was 16.47- 61.59 U·L^-1. While the activities of ALT and total bilirubin were elevated and AST was normal in affected sheep. ALT and total bilirubin level was higher than normal (P<0.01), and the AST activity of sick sheep and lamb was not significantly different with healthy sheep (P>0.05). 205 experimental sheep had fungal infections; Pithomyces, Alternaria, Fusarium and Aspergillus isolated from diseased goats had higher separation rate than that of the others. The Pithomyces separation rate was highest. Others such as yeast, Rhizopus and Mucor were also separated in all sheep, but the separation rates were low. The results revealed that the facial eczema was hepatogenic light allergic eczema caused by hepatic dysfunction and hepatonecrosis in grazing sheep in the area, and the pathogen may be Pithomyces, Alternaria, Fusarium and Aspergillus.

中图分类号:

S826
S852.3

刘良波，韩玉霞，孙焕林，柳建新，杨祎，王建华，卜万喜，齐亚银，剡根强. 天山北坡放牧绵羊面部湿疹的临床病理学研究[J]. 畜牧兽医学报, 2013, 44(9): 1481-1486.

LIU Liang-bo, HAN Yu-xia, SUN Huan-lin, LIU Jian-xin, YANG Yi,WANG Jian-hua, PU Wan-xi, QI Ya-yin, YAN Gen-qiang. Clinicopathological Studies on Facial Eczema Outbreak in Grazing Sheep in Northern Slope of Tianshan Mountain[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(9): 1481-1486.

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天山北坡放牧绵羊面部湿疹的临床病理学研究

Clinicopathological Studies on Facial Eczema Outbreak in Grazing Sheep in Northern Slope of Tianshan Mountain

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